ObjectiveTo analyze the influences of sufentanil combined with remifentanil on surgical effect, hemodynamics and restlessness at the stage of analepsia in pediatric tonsil surgery under general anesthesia with sevoflurane.MethodsA total of 106 children who received scheduled tonsillectomy in the First People's Hospital of Kashgar from Oct. 2015 to Dec. 2017 were selected and divided into control group (n=53) and experimental group (n=53) according to the random number table method. Induction anesthesia was implemented with remifentanil in the control group, with sufentanil and remifentanil in the experimental group. The operation time, anesthesia time, time of drug withdrawal to extubation, time of awakening, recovery time of spontaneous breathing, and time out of postanesthesia care unit were compared between the two groups. The heart rate (HR), mean arterial pressure (MAP) and blood oxygen saturation (SpO2) of the two groups were recorded and compared at time points of preinduction, intubation, 5 min after intubation and 5 min after extubation. The Aono ’s score, the paediatric anesthesia emergence delirium (PAED), and children and infants postoperative pain scale (CHIPPS), as well as the incidences of adverse reactions after anesthesia were also compared between the two groups.ResultsThe time of awakening［(8.2±2.7) min］, recovery time of spontaneous breathing［(115.7±32.4)s］, and time out of postanesthesia care unit［(28.4±6.3) min］ in the experimental group were significantly shorter than those in the control group, and all the differences were statistically significant (all P<0.05). The HR and MAP at time points of 5 min after intubation and 5 min after extubation in the experimental group were significantly lower than those of the control group, and both the differences were statistically significant (both P<0.05). The differences in SpO2 at time points of 5 min after intubation and 5 min after extubation between two groups were statistically insignificant (both P>0.05). The Aono’s score, PAED score and CHIPPS score in the experimental group were evidently lower than those in the control group (all P<0.05). The incidences of nausea and vomiting and the total incidence of adverse reactions in the experimental group were remarkably lower than those in the control group (all P<0.05).ConclusionSufentanil combined with remifentanil can enhance the effect of anesthesia in children, improve the hemodynamic level, reduce the restlessness at the stage of analepsia, and reduce the incidences of adverse reactions.