ObjectiveTo analyze the effect and influential factors of sublingual desensitization of acaridrelated allergic rhinitis in children.MethodsA retrospective analysis was made of the data of 532 pediatric patients admitted to the department of otolaryngology head and neck surgery of Hunan Children's Hospital from January 2017 to July 2017. And the patients were diagnosed as acaridrelated allergic rhinitis and treated with sublingual desensitization through skin pricking test. A comparison of the factors of groups were performed on their gender, length of disease, whether single mite (dust mite) allergy, whether combined asthma, treatment compliance, whether to take personalized treatment, medication course, whether to take antimite measures, skin pringling test and other factors.ResultsBy the singlefactor analysis method, among the 532 cases of desensitization treatment, at the confidence level of 10% (P<0.10),the influencing factors of the efficacy of sublingual desensitization therapy were the types of allergens, course of disease, combined asthma, personalized treatment, treatment compliance and duration of medication. Subsequently, multifactor analysis was used to analyze the results of 532 cases of desensitization treatment. And at the confidence level of 5% (P<0.05),the course of disease, types of allergens, combined asthma, treatment compliance, personalized treatment and course of medication are the influential factors of the efficacy of sublingual desensitization.ConclusionsThe shorter the course of the disease is the better its treatment enough for the pediatric patients of sublingual desensitization. The patients without asthma have better curative effect. The treatment compliance is better, and the effects of individualized treatment is better. The patients with single dust mite allergy have better efficacy. The gender and skin prick test had no effect on the curative effect.