Abstract:ObjectiveTo explore the types of gene mutation and the rehabilitation effect after cochlear implantation in 43 patients in southern Sichuan, and evaluate their correlation.MethodsGJB2, SLC26A4, and mtDNA 12S rRNA genes were detected in 43 patients with deafness. The patients with diseasecausing mutations were classified as group A, and those without mutations as group B. Unilateral cochlear implantation was performed in all patients of both groups. Their categories of auditory performance (CAP) and speech intelligibility rating (SIR) were evaluated before surgery and at 3, 6 and 12 months after surgery.ResultsThere were 14 cases in group A (n=14) with a positive rate and 29 in group B (n=29). Of the 14 cases in group A, 9 were positive for GJB2, 6 for SLC26A4, 1 for GJB2 and SLC26A4, and none for mtDNA12SrRNA. The CAP and SIR scores of both groups were significantly improved at different time points within 1 year after operation, and the scores gradually increased with the prolongation of postoperative time (P<0.05). But the differences of both CAP and SIR scores between the two groups at all time points were statistically insignificant (all P>0.05).ConclusionsThe common gene mutations in the 43 patients are GJB2 and SLC26A4. Cochlear implantation can effectively improve their hearing and speech ability. There is no significant correlation between the deafness gene mutation and the rehabilitation effect after cochlear implantation.