ObjectiveTo investigate the protein expression of Zwint1, and the correlation between Zwint1 expression and clinicopathological characteristics in head and neck squamous cell carcinoma (HNSCC).MethodsThe expression of Zwint1 in 16 HNSCC tissues and 7 normal tissues was detected with immunohistochemistry. An HNSCCrelated tissue microarray was used to analyze the correlation between Zwint1 expression and clinicopathological characteristics of this tumor.ResultsImmunohistochemistry showed that the expression of Zwint1 in HNSCC was higher than that in the normal tissues (P<0.05). The results of tissue microarray revealed that Zwint1 expression level was correlated with the size, lymphatic metastasis, differentiation, clinical stages of HNSCC (all P<0.05). However, chisquare tests showed that there were no statistical correlations between Zwint1 positive expression and abovementioned parameters (all P>0.05).ConclusionZwint1 plays an important role in the oncogenesis and development of HNSCC, which may be a potential therapeutic target of this tumor.