ObjectiveTo analyze the prognosis and affecting factors for surgical treatment of glottic cancer.MethodsClinical data of 226 patients who were initially diagnosed as glottic cancer and underwent surgical treatment in our hospital from June 2008 to April 2013 were analyzed retrospectively. The analyzed data included patients’ gender and age, T stage and N stage of tumor, surgical manner, postoperative radiotherapy, pathological classification, surgical outcomes and so on. The logrank test was used for univariate analysis, and Cox proportional risk regression model for multivariate analysis. 5year survival rate was calculated by KaplanMeier method.Results①Univariate analyses showed that the patients’ age，T stage and N stage of tumor，postoperative radiotherapy, pathological classification, local recurrence，recurrence of lymph nodes were related to the prognosis of the tumor (all P<0.05). ②Multivariate analyses revealed that the patients’ age，T stage and N stage of tumor，recurrence of pharynx, larynx or tracheostoma, and recurrence of lymph nodes were independent prognostic risk factors (all P<0.05). ③The overall 5year survival rate of these 226 cases was 75.2%.ConclusionReasonable cervical lymph node dissection and postoperative radiotherapy can improve the prognosis of patients with locally advanced glottic cancer. Patients of stage III~IV have a high risk of postoperative local/cervical lymph node recurrence, which requires close followup. Active salvage surgery is still the main treatment for recurrent patients.