Abstract:ObjectiveTo investigate the clinical, imaging examination and clinicopathological features of rhabdomyosarcoma in children, so as to reduce the misdiagnosis and missed diagnosis for improving clinical diagnosis and differential diagnosis.MethodsThe clinical data of 3 cases of rhabdomyosarcoma in atypical preschool children were retrospectively analyzed and the related literatures were reviewed.Results2 cases complained mainly of ocular symptoms, 1 case complained mainly of recurrent nasal bleeding and snoring. The imaging examination showed that most of the tumors had invaded and destroyed the surrounding structures, and most of them were diagnosed for embryonic rhabdomyosarcoma by operation and pathology. Immunohistochemistry showed that Myogenin was positive in all 3 patients, Ki67 (LIt was about 90%, 80% and 70%, respectively), 2 patients were positive for VIM, 2 patients were positive for DES (partial or focal), and 2 patients were positive for CD99. Then,they were transferred to the department of oncology, and treated regularly.ConclusionsThe early clinical manifestations of rhabdomyosarcoma in children are atypical and diversified. It has the characteristics of high malignancy, strong invasiveness and rapid progress. The diagnosis needs to be confirmed according to the clinical features, combined with imaging examination and immunohistochemical results.