ObjectiveTo explore the improvement of residual symptoms after reduction in patients with benign paroxysmal positional vertigo (BPPV) by drug therapy combined with vestibular rehabilitation training.MethodsSixtysix patients who suffered from BPPV and were successful in the reduction of calculus in our hospital from June 2013 to Feb 2016 were enrolled. According to the random number table method, they were equally divided into drug group, vestibular rehabilitation group, and combination group. The dizziness handicap inventory (DHI) and hospital anxiety and depression scale (HADS) scores before and after treatment were compared. All the patients were followed up for 6 months after treatment, and the recurrence rates were recorded.ResultsAt 2, 4, 6 weeks of treatment, the DHI score of the combination group was significantly lower than those of the vestibular rehabilitation group and the drug group, and the differences were statistically significant (both P<0.05). At 6 weeks of treatment, the HADST score of the combination group was significantly lower than those of the vestibular rehabilitation group and the drug group, and the differences were statistically significant (both P<0.05). The recurrence rate of the combination group was lower than those of the drug group and the vestibular rehabilitation group, the differences were statistically significant (χ2=3.511, 2.387, both P<0.05).ConclusionFor BPPV patients with successful reduction of calculus，drug therapy combined with vestibular rehabilitation training can achieve complete remission of residual symptoms, reduce the recurrence rate of vertigo, and relieve patients’ anxiety and depression.