ObjectiveTo analyze the consistencies of pepsin test strip, DxpH monitoring, reflux symptom index (RSI) and reflux finding score (RFS) scales in patients with laryngopharyngeal reflux disease (LPRD).MethodsClinical data of 110 patients with laryngeal diseases hospitalized in our department from Aug 2017 to Feb 2019 were analyzed retrospectivel. The RSI and RSF values, Ryan index of DxpH monitoring and the results of pepsin test strip were recorded, and their correlations were analyzed by Kappa method.ResultsOf the 110 patients, pepsin test showed positive result in 75 cases with a positive rate of 68.18%, and the positive rate of DxpH detection was 22.73%, the diagnostic consistency rate between the two methods was 41.82%. The positive rate of RSI and RFS values was 90%, which was more consistent (k=0.324) with pepsin reflux test (74.55%) than the DxpH monitoring . Taking the DxpH monitoring as the reference, the sensitivity and specificity of pepsin test strip was 72% (18/25) and 32.94% (28/85). Taking the RSI and RFS scales as the reference, the sensitivity and specificity of pepsin test was 71.73% and 81.82%,respectively, with a positive predictive value of 97.33%.ConclusionsThe consistency between RSI/ RSF score and the pepsin test strip is higher than that of other examinations. As a new noninvasive diagnostic technology, although pepsin test can not be the golden criterion for the diagnosis of LPR, it can be widely used combining with DxpH monitoring and RSI and RFS scales in clinical practice.