ObjectiveTo analyze the progression and possible influence factors of Kimura’s disease (KD) after treatment.MethodsA retrospective analysis was conducted on 59 patients with KD hospitaled in our department from Oct 2007 to June 2019. Data collected by telephone followup included gender, onset age, smoking history, drinking history of patient, course of disease, multiplicity, laterality, location and maximal diameter of lesion, eosinophils percentage in peripheral blood, history of recurrence, pruritus, systemic diseases, treatment modality. Univariate analysis and binary logistic regression analysis were performed by SPSS 21.0.ResultsFiftynine cases were included with a disease progression rate of 37.3%. Univariate analysis showed peripheral eosinophils ≥20%, maximal diameter of lesion, pruritus and history of recurrence were positively related to the progression of KD (all P<0.05). Binary logistic regression analysis revealed that peripheral eosinophils ≥20% was an independent risk factor (P<0.05).ConclusionThe peripheral eosinophils ≥20% is an independent risk factor for the progression of KD after treatment, which can help predict the therapeutic effect and facilitate the individualized precise treatment of this disease.