ObjectiveWith the development of the endotypes classification and blood markers of chronic rhinosinusitis(CRS), the treatment of CRS has ushered in the era of precision medicine. This paper summarizes the endotypes classification of CRS, and the relationship between CRS endotypes types and blood markers. And the article focuses on the progress of the current research for CRS blood markers led by type 2 inflammation blood markers in CRS. We hope to find blood markers that are more suitable for clinical detection, which will lay the foundation for establishing the corresponding endotypes classification of CRS. It will guide the better personalized treatment of CRS and evaluate the prognosis of CRS.