174例喉癌患者手术预后及影响因素分析
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刘环海,Email:liuhuanhaiok@126.com

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国家自然科学基金(81770980, 81870702, 81670905)。


Analysis of surgical prognosis and influencing factors in 174 laryngeal carcinoma patients
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    摘要:

    目的探讨喉癌患者接受手术治疗后的生存情况及预后影响因素。方法回顾性分析2010—2014年上海长征医院耳鼻咽喉头颈外科经手术治疗的174例原发性喉癌患者的临床资料,男164例,女10例;年龄35~87岁,平均年龄(60.73 ± 9.88)岁。通过KaplanMeier模块进行单因素分析,Cox比例风险模型行多因素分析,分析喉癌患者预后的独立影响因素。结果全组患者共174例,5年生存率64.4%;喉癌早期T1、T2期患者5年生存率达到77%。单因素分析结果显示,临床分期、病理分化程度、并发症、T分期、N分期、手术方式、颈淋巴结清扫术、肿瘤原发部位与喉癌患者术后5年生存率相关。Cox多因素分析结果显示,T分期和N分期是影响喉癌预后的独立危险因素。结论T分期、N分期是影响喉癌患者生存率的独立因素。

    Abstract:

    ObjectiveTo investigate the survival and prognostic factors of patients with laryngeal carcinoma after surgical treatment.MethodsClinical data of 174 patients with laryngeal carcinoma surgically treated in Shanghai Changzheng Hospital from 2010 to 2014 were analyzed retrospectively. Of them, 164 were male and 10 were female. Their age ranged from 35 to 87 years old with an average of (60.73±9.88). To determine the independent prognostic factors of laryngeal carcinoma patients, the single factor analysis was conducted by Kaplan Meier module, and the multiple factor analysis was conducted by Cox proportional risk model.ResultsThe overall 5year survival rate was 64.4% and that of the early stage patients (T1 and T2) was 77%. Univariate analyses showed that clinical stage, pathological differentiation, complications, T stage and N stage, operation mode, neck lymph node dissection, primary site of tumor were related to the 5year survival rate. Cox multivariate analyses showed that T stage, N stage were independent risk factors for prognosis of laryngeal carcinoma.ConclusionT stage, N stage, degree of pathological differentiation and complications are independent factors affecting the survival rate of patients with laryngeal carcinoma.

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邹庆云,刘映岐,查旭东,周梦夏,梁才全,王天宇,蔡博宇,杜昱聪,彭浒,刘环海.174例喉癌患者手术预后及影响因素分析[J].中国耳鼻咽喉颅底外科杂志,2020,26(4):421-425

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  • 在线发布日期: 2020-08-27
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