ObjectiveTo provide clinical experience for the diagnosis and treatment of laryngeal inflammatory myofibroblastic tumour (IMT) by analyzing and discussing the clinical manifestations and histopathological characteristics as well as followup outcomes of this tumour.MethodsClinical data of 4 patients with laryngeal IMT treated in our hospital from Oct 2007 to June 2019 were analyzed retrospectively. The analyzed data included clinical manifestations, histopathological features, treatment methods and prognosis.ResultsThe lesions were located in the glottic and supraglottic compartments in all the 4 patients. Microlaryngoscopic or open surgery was selected according to the extent of lesion and severity of illness. All the postoperative specimens were examined histopathologically with immunohistochemical results as follows: Vimentin (+), smooth muscle actin (SMA) (partial +), Desmin (-), CK (-), Ki67 (+) ≤45%, anaplastic lymphoma kinase (ALK) (-), CD34 (vascular +) and CD68 (±). Postoperative followup ranged from 25 to 140 months revealed that all patients were in good health without recurrence or metastasis except one died of other disease.ConclusionLaryngeal inflammatory myofibroblastoma is a lowgrade malignant head and neck tumour with relapse potential, and its diagnosis depends on histopathological and immunohistochemical examinations. Surgical resection is the preferred treatment method for the disease with postoperative radiotherapy and chemotherapy if necessary.Postoperative close followup is required.