ObjectiveTo investigate the diagnosis and treatment of primary amyloidosis of laryngeal.MethodsThe retrospective study comprises the clinical data of 5 patients with localized amyloidosis of laryngeal surgically treated in the department of Otorhinolarynology, Shaanxi Provincial People’s Hospital from January 2014 to January 2017. It was analyzed for symptoms, auxiliary examinations, diagnosis and treatments of patients. The clinical features of 5 patients were all hoarseness. The lesions of primary amyloidosis were located in the larynx(3 cases), including false vocal folds(3 cases), subglottis（2 cases）and trachea(2 cases). Four patients with primary laryngeal amyloidosis were conducted of CO2 laser excision, who were assisted by general anesthesia in microlaryngoscopy and in microsurgery of the larynx.ResultsThe hoarseness symptoms of the patients were significantly improved postoperative. The patients had not dyspnea, or other symptoms of discomfort. One cases of the patients recurred within the first year after surgical treatment. The other patient’s condition was stable without obvious recurrence during followup.ConclusionsThe symptoms and auxiliary examination of laryngeal amyloidosis are lack of specificity. The diagnosis of amyloidosis usually depends on pathological examination. Up to now, it has been not any ways to cure amyloidosis directly. Surgery therapy of localized laryngeal amyloidosis is the key way to obtain a long diseasefree interval with preservation of a good voice and absence of dyspnea.