ObjectiveTo investigate the surgical method and therapeutic effect of endoscopic surgery for anasal sinus osteoma, and to summarize the experience of surgery for nasal sinus osteoma.MethodsIt was retrospectively analyzed for the clinical data of 11 cases of osteoma of nasal sinus including 5 cases of nasal obstruction, 2 cases of epiphora, 1 case of exophthalmos, 1 case of headache and 2 cases of visual impairment. These patients were treated by endoscopic surgery in the Guizhou Provinical People's Hospital from May 2012 to June 2016. All patients were preoperatively examined by threedimentional computed tomography(3D CT)in order to judge Osteoma’s location and scope of invasion.The patients were examined for visual acuity, visual field, Optic nerve evoked potential (VEP) and optical coherence tomography (OCT) before surgery.The anesthesia methods were general anesthesia and controlled hypotension.All operations were performed under nasal endoscopy.During the operation, specific surgical methods were selected according to the CT scope of the sinus, and the constant anatomical structure was selected as a marker to achieve the complete the resection as far as possible to remove osteoma. Nasal septum pedicled mucosal flap was used to cover the operative cavity to promote the epithelialization of the operative cavity. The patient was reexamined with sinus CT one week after surgery, which received regular outpatient followup after operation.ResultsCT scan of nasal sinuses showed that 9 cases were completely resected and 2 cases were partially resected after operation. All patients were followed up for 26~76 months. The preoperative symptoms of the patients improved significantly including the symptoms of headache, nasal obstruction and epiphora disappeared. 1 case had partial improvement in vision, but 1 case about exophthalmos recurred after a year,which was transferred to another hospital.The patient has been lost to followup, and no tumor recurrence was found in the other patients.ConclusionsEndoscopic surgery is safe, effective and minimally invasive in the treatment of osteoma of nasal sinus. Preoperative CT of nasal sinus can provide reliable guarantee for endoscopic surgery. Constant anatomical structure is selected to locate the tumor boundary during operation in order to achieve complete resection of osteoma.