ObjectiveTo analyze the clinical value of highresolution manometry (HRM) of the pressure of the upper esophageal sphincter(UES) in patients with laryngopharyngeal reflux disease (LPRD).Methods71 patients with pharyngeal paraesthesia symptoms and 28 normal subjects underwent HRM of UES pressure. On the basis of RSI score, 71 patients were divided into pharyngeal reflux group (group A, 31 cases, RSI>13 points) and without pharyngeal reflux group (group B, 40 cases, RSI ≤ 13 points), normal subjects group(group C,28 cases). There was no statistical difference in sex ratio, mean age and BMI among the three groups (all P>0.05).ResultsThe SF36 score in group A (91.44±4.17) was obviously lower than that in group B (99.51±5.86) and in group C (114.03±5.29) (all P<0.05). The mean USE resting pressure of three groups were (104.50±33.84) mmHg(group A), (76.34±20.08) mmHg(group B) and (46.92±11.56) mmHg(group C) respectively, and which was significantly higher in group A than in group B and C (P<0.05). The mean residual pressure of three groups were (26.31±8.27) mmHg(group A), (15.40±7.19) mmHg(group B) and (10.25±4.74) mmHg (group C)respectively, and which was significantly higher in group A than in group B and C(all P<0.05). The average distal contraction integral (DCI) and distal latency (DL) in three groups were no statistically significant.ConclusionThe life quality score of patients with LPRD was lower, and the onset of the symptoms might be correlated with the increasing resting pressure and residual pressure of UES. The measurement of UES resting pressure and residual pressure could be valuable for the diagnosis and prognosis of LPRD.