ObjectiveTo observe the expression of microRNA107 (miR107) in laryngeal carcinoma and paracarcinoma tissues, and to detect its effect on migration and invasion of laryngeal carcinoma cells via selective upregulation and knockdown of miR107 in laryngeal carcinoma cell lines.MethodsThe carcinoma and paracarcinoma tissues were obtained from 40 patients with laryngeal carcinoma. The expression of miR107 was detected by quantitative realtime polymerase chain reaction (RTqPCR) and its clinical significance in laryngeal carcinoma was analyzed. The effect of miR107 on migration and invasion of laryngeal carcinoma cells was detected by Transwell via overexpression or knockdown of miR107 in human laryngeal carcinoma cells TU212 and TU686.ResultsThe expression of miR107 in laryngeal carcinoma tissue was significantly lower than that in paracarcinoma tissue (P<0.05). The expression level of miR107 was correlated with tumor cell differentiation, lymph node metastasis and primary site (all P<0.05). Cell experiments showed that the migration and invasion abilities of laryngeal carcinoma cells were significantly decreased after overexpression of miR107 (P<0.05), and significantly increased after knockdown of miR107 (P<0.05).ConclusionThe expression of miR107 is significantly downregulated in laryngeal carcinoma, which can inhibit the migration and invasion of laryngeal carcinoma cells.