ObjectiveTo analyze the difference of serum calcium in laryngeal cancer patients with different genders.MethodsA total of 33 female patients with laryngeal cancer who received treatment were selected for clinical analysis, and 60 healthy women who underwent physical examination were randomly selected as the control group in Qingdao Municipal Hospital from 2001 to 2018. And 121 male patients with laryngeal carcinoma and 121 healthy men were randomly selected for clinical analysis.ResultsAmong the 33 female patients with laryngeal cancer, the serum calcium level of 25 patients decreased to (1.94±0.11) mmol/L.The serum calcium of female laryngeal cancer patients was lower than that of the female healthy control group (2.31±0.11) mmol/L, and the difference was statistically significant(P<0.05). The serum calcium of male patients with laryngeal cancer was (2.32±0.21) mmol/L compared with that of healthy male control group (2.31±0.23) mmol/L. There was no significant difference in serum calcium between male patients with laryngeal carcinoma and healthy men(P>0.05).ConclusionThe decrease of serum calcium in laryngeal carcinoma may be involved in the occurrence and development of laryngeal carcinoma in women and not in men， which provides some guidance for clinical screening of female laryngeal carcinoma.