ObjectiveTo analyze the clinical application value of low temperature plasma removal of uvula mucosa combined with inverted suture and suspension in the surgical treatment of moderate obstructive sleep apnea hypopnea syndrome(OSAHS).MethodsClinical data of 32 patients suffering from moderate OSAHS confirmed by polysomnography (PSG) and surgically treated were analyzed retrospectively. All the patients received druginduced sleep endoscopy (DISE) for evaluating the obstruction of upper airway and were equally divided into two groups. The 16 cases of the control group were treated with conventional Hanuvulopalatopharyngoplasty (HUPPP), while those of the experimental group received low temperature plasma removal of uvula mucosa combined with inverted suture and suspension based on the HUPPP. Their subjective symptoms and postoperative complications were evaluated according to Epworth sleepiness scale (ESS) and snoring scale scores, and analyzed statistically using SPSS software.ResultsComparisons between preoperative and postoperative ESS score as well as snore scale score showed significant improvement in the patients of both groups, and the differences were all statistically significant (all P<0.05). There were no statistically significant differences in ESS score and snore scale scores between the two groups (all P>0.05). The differences of operative time and intraoperative blood loss between the two groups were statistically significant (both P<0.05). The difference of postoperative pain score between the two groups was statistically significant (P<0.05), and the experimental group was significantly better than the control group. The occurrence rates of postoperative complications including pharyngeal foreign body sensation, pharyngeal dryness and pharyngeal tension in the experimental group were lower than those in the control group, and the differences were all statistically significant (all P<0.05). Permanent palatopharyngeal insufficiency, perioperative dyspnea, perioperative death and postoperative difficult extubation were observed in none of both groups. ConclusionWith advantages of mild postoperative reaction and subjective symptom, low incidence of complication as well as definite shortterm curative effect, low temperature plasma removal of uvula mucosa combined with inverted suture suspension is worthy to be clinically popularized and applied in the surgical treatment of moderate OSAHS, especially for those with the palatopharyngeal plane and oropharyngeal lateral wall as the main responsibile narrow plane.