Objective To detect the correlation between the invasiveness and texture of pituitary adenomas (PA). Methods 76 cases of PA being verified surgically and pathologically were collected at our hospital from January 2008 to January 2010,then were divided into different groups based on different criteria: invasive group (32 cases) and noninvasive group (44 cases) according to their MRI finding; hard group (22 cases) and soft group (54 cases) in texture according to surgical finding. Immunohistochemical staining (SP method) was used for detecting the expression of Ki67 and MMP2 (matrix metalloproteinase2) in these samples of PA. The correlation between the invasiveness and the expressions of Ki67 and MMP2, and the correlation between the invasiveness and the texture of PA was statistically analyzed. Results The expression of Ki67 and MMP2 in invasive group was7.573±3.991 and 18.623±9.689 respectively, which significantly higher than the one in non-invasive group (2.811±2.095 and 6.871±7.230, t1=6.161, t2=5.788, P<0.01). Ki67 was positively correlated with MMP2 (r=0.476, P<0.01). There was no correlation being found between the invasiveness and the texture of PA (P=0.056). Conclusion Ki-67 and MMP2 can be used as molecular markers to evaluate the invasiveness of PA, therefore to guide the individual therapy. The texture of PA can not be determined simply by its radiological features of invasiveness.