Objective To investigate the safety and efficacy of 3D printing nasal bone reduction device in closed reduction. Methods Eighty-five cases of nasal bone fracture were consecutively enrolled in our department from Nov 2017 to June 2020. Of them, 41 treated with traditional nasal bone reduction device were assigned to the control group and 44 patients treated with 3D printing nasal bone device to the experimental group. Clinical data of 39 patients in the control group and 39 in the experimental group were eventually analyzed. Visual analogue score (VAS) was used to evaluate the patient satisfaction. The surgical effect was classified as ‘excellent’, ‘good’ and ‘fair’ according to postoperative CT scans. Results The preoperative appearance score and nasal congestion score were 6±3 and 3±3 in the control group, 6±4 and 3±4 in the experimental group. The postoperative appearance score and nasal congestion score were 2±2 and 1±1 in the control group, 1±2 and 1±0 in the experimental group. As for the surgical effect, 23 cases were shown as ‘excellent’, 13 as ‘good’, and 3 as ‘fair’ in the control group, and the case numbers of ‘excellent’, ‘good’ and ‘fair’ were 32, 6 and 1 in the experimental group. Conclusions Either 3D printing nasal bone reduction device or traditional nasal bone reduction device can greatly improve patients' nasal appearance and ventilation in closed reduction. It is easier to achieve accurate anatomical reduction of nasal bone fracture by using 3D printing nasal bone reduction device.