Objective To report the medical records of two patients with auricular perichondritis after endoscopic tympanic mem-brane repair for the purpose of clinical reference. Methods Two patients with auricular perichondritis after endoscopic tympanic membrane repair were treated with anti-inflammatory and symptomatic treatment, and the abscess was extensively cut open and drained to clean the necrotic cartilage. This paper analyzed the etiology, clinical characteristics and treatment of auricular perichon-dritis by combining literature review. Results Patient No. 1 was followed up for 4 months, who had slightly collapsed deformity at the upper portion of the right auricle. The repaired tympanic membrane healed well. The patient's conscious hearing improved. Acoustic impedance showed Type A. Pure tone audiometry showed that the air bone conduction difference basically disappeared. In the second patient, there was no local exudation from the wound after 2 months of follow-up, and the incision gradually healed in para-position. Conclusions Due to the extensive development of tympanic membrane repair technology, the operation of tragus carti-lage has increased. Clinicians need to be alert to the occurrence of auricular suppurative chondritis. Strict disinfection during the operation and observation and nursing care after the incision. Early diagnosis and treatment should be performed after the occurrence to minimize auricle deformities.