Objective To analyze the clinical effect of three-stage therapy for rhinitis medicamentosa and provide reference for clinical treatment. Methods Seventy-eight cases of rhinitis medicamentosa were divided into oral medicine group (n=12) and nasal decongestant group (n=66) according to their pathogenic causes. These cases were treated with topical nasal steroids+ antihistamine (the first stage therapy), topical nasal steroids+ antihistamine + Hypertonic saline (the second stage therapy) and surgical treatment (the third stage therapy). VAS score, Lund-Kennedy scale of nasal endoscopy and nasal airway resistance examination were used to evaluate the effect of treatment at different stages of treatment between two groups. Results The cured cases were 100%(12/12) after the first and second stage treatment in oral medicine patients. The first/second/third stage treatment were used in the nasal decongestant cases of rhinitis medicamentosa with 1.5%(1/66), 18.5%(12/65) and 94.3%(50/53) cure rates, respectively. Conclusion It is worthy of clinical recommendation for application of stage-therapy as a treatment for rhinitis medicamentosa.