Lacrimo-auriculo-dento-digital (LADD) syndrome is a hereditary disease involving in multiple systems. The main manifestations of LADD have lacrimal duct hypoplasia, ear and hearing abnormalities, salivary system hypoplasia, tooth abnormalities and finger dysplasia. At present, it is confirmed that fibroblast growth factor receptor 2 (FGFR2), fibroblast growth factor receptor 3 (FGFR3) and fibroblast growth factor 10 (FGF10) are the causes of the disease. The incidence rate of this disease is low, and its symptoms overlap with other diseases, which are not reported in China. The lack of knowledge of the LADD syndrome is likely to cause missed diagnosis and misdiagnose. This article summarizes the genotype and characteristics of the disease. The clinical symptoms of the LADD were retrospectively and systematically analyzed in order to improve the understanding of the disease.