Objective To improve the understanding, diagnosis and treatment of concha bullosa mucocele of the middle turbinate.Methods This paper reported the clinical data of a case of concha bullosa mucocele of the middle turbinate, and reviewed the relevant literature. The patient was followed up for postoperative recovery.Results The patient underwent the left resection of the concha bullosa mucocele of the lateral partial middle turbinate under nasal endoscope.The patient recovered well with clear nasal anatomy, and preserved the nasal function.Conclusion Concha bullosa mucocele of the middle turbinate is a common anatomical variation of nasal cavity. It can be found during physical examination or when the patients present with relevant symptoms. Because its development is slow and its symptoms are diverse, it is very easy to miss diagnosis or misdiagnosis. Endoscope operation is the best treatment to this disease. The specific operation is combined with individual treatment of patients.