Inverted sinonasal Papilloma (ISP) is a kind of benign tumors of the nasal and paranasal sinuses. The preferred treatment for ISP is surgical treatment, which is different from the benign tumors due to the three characteristics of local invasive growth, recurrence tendency and malignant transformation. Therefore, ISP’s initial surgical treatment and postoperative follow-up are very important.At present, the diagnosis, treatment and follow-up of ISP are mainly based on imaging, pathology and endoscopic technologies. However, due to the unclear mechanism of ISP occurrence, ISP molecular biological mechanism is rarely used to guide ISP diagnosis and treatment. Therefore, the study of ISP-related molecules is helpful to explore the key genes affecting ISP and provide new ideas and favorable evidence for the diagnosis and treatment of ISP.In recent years, scholars at home and abroad have done a lot of research on the expression of some factors in ISP. In this paper, the relevant literatures at home and abroad are systematically reviewed. This paper summarized and analyzed the research on ISP-related molecules.