Abstract:Objective To investigate the relationship between blood routine and biochemical indexes and sleep apnea hypopnea index (AHI) in male patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods A retrospective study was performed on 474 adult male patients who underwent surgery in our department from Jan 2011 to Dec 2019 and had complete sleep monitoring data prior to admission. According to AHI, patients were divided into four groups:Group A (AHI<30 times/h, n=56), group B (30 times/h ≤ AHI<60 times/h, n=162), group C (60 times/h ≤ AHI<90 times/h, n=217), and group D (AHI ≥ 90 times/h, n=39). Data collected included sleep parameters, the Epworth Sleeping Scale, blood routine and biochemical indexes and demographic characteristics.Results There were statistically significant differences in red blood cell count, platelet count, white blood cell count, neutrophils, alanine aminotransferase (AST), aspartate aminotransferase (ALT), AST/ALT, glucose, uric acid, triglyceride and high-density lipoprotein among the four groups (P<0.05). With good linear correlations between high-density lipoprotein and triglycerides and AHI, the former showed negative correlation while the latter showed positive correlation (r=-0.252, r=0.192). Multiple linear regression analysis showed that erythrocyte count (β=0.140, P=0.004) and triglyceride (β=0.122, P=0.017) were independently correlated with AHI, with multiple correlation coefficients R2=0.332.Conclusion With good linear correlations, high-density lipoprotein is negatively and triglyceride is positively correlated with AHI(r=-0.252,r=0.192), and the red blood cell count and triglyceride are independently correlated with AHI, which have the potential to be auxiliary indicators to judge the comprehensive severity of OSAHS patients diagnosed with polysomnography.