Objective To investigate the effect of Xueshuantong injection in the treatment of sudden deafness complicated with metabolic syndrome and its effect on serum hemorheology.Methods A total of 100 patients with sudden deafness complicated with metabolic syndrome admitted to General Hospital of Huainan Oriental Hospital Group from October 2017 to October 2019 were selected and randomly divided into two groups:the control group (n=50) was given the routine treatment of batroxase,supplementation of vitamins and neuronutrition; the observation group (n=50) was treated with Xueshuantong injection on the basis treatment of the control group. The differences between the two groups before and after treatment were compared, including hearing threshold and serum hemorheology indexes of plasma viscosity, whole blood viscosity, thrombin time, prothrombin time, activated partial prothrombin time, fibrinogen and platelet factor.Results After treatment compared to before treatment, plasma viscosity and whole blood high-cut viscosity, medium-cut viscosity and low-cut viscosity were significantly decreased in two groups, but the levels of thrombin time, prothrombin time, activated partial prothrombin time, Connexin 26 and Connexin 30 were significantly increased; After treatment, the hearing threshold of 2 groups was significantly lower, and the improvement degree of the corresponding indicators in the observation group was significantly higher than that in the control group, which was statistical significance (P<0.05).Conclusion Xueshuantong injection combined with Batroxase can effectively improve the hypercoagulability of blood in patients with sudden deafness complicated with metabolic syndrome, increase the levels of serum connectin 26 and connectin 30, and effectively improve the microcirculation and hearing of patients.