Object: To explore the clinical features, therapy strategy and outcomes of patients with traumatic interhemispheric subdural hematoma (TISH). Methods: the clinical data of 29 TISH patients admitted in Neurosurgery department of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from August, 2014 to May, 2019, was retrospectively collected and analyzed. The short-term outcome was evaluated by Glasgow outcome scale (GOS) on two weeks after corresponding treatment. Results: The good curative effect was achieved in 20 cases (69.0%), while the poor outcome was identified in 9 cases (31.0%). The mean GCS on two weeks after treatment was evaluated as 14.6±0.7 in good outcome group, which was significant better than that in poor outcome group (9.4±2.2) (p<0.001). Univariate analysis demonstrated various factors affecting the TISH outcome, such as cerebral contusion (0.032), GCS score at admission (p<0.001), GCS score decreased during hospitalization (p=0.049), and extreme GCS value during hospitalization (p<0.001), treatment (p=0.016) and surgical approach (p<0.05). In severe TISH patients (GCS ≤ 8), 7 patients were treated surgically and three cases received non-surgical treatment. The short-term outcome in surgery group was evaluated as good in 4 cases (57.2%) and poor in 3 patients (42.9%); while the short-term prognosis was poor in all patients in the non-surgical group (n=3). Conclusion: The incidence of TISH was rare. Most TISH was mild illness which might achieve a good outcome by medication treatment. Similarly, a good outcome could be obtained by neuro-monitoring and neurosurgical treatment in some severe cases with delayed hemorrhage, increased intracranial pressure and nerve dysfunction.