circRNA在喉癌中作用机制的研究进展
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1.贵州医科大学;2.贵州医科大学附属医院;3.贵州医科大学附属白云医院

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贵阳市白云区科技计划项目(白科合同[2019]38号)


Mechanism research progress of circRNAs in laryngeal carcinoma
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    摘要:

    circRNA(circular RNA)是一类不包含5’帽状结构和3’腺苷酸尾,并共价形成闭环的内源性的非编码RNA。由于其特殊的环状结构,因此其对核酸外切酶有更高的耐受性,比线性RNA更稳定。circRNA被报道参与了广泛的生物学过程,在各种肿瘤中的发生、发展过程中起着重要的作用,有可能成为肿瘤理想的治疗靶点。有文献报道,circRNA的异常表达与喉癌的发生、发展密切相关。本文对国内外相关文献中多个与喉癌关系紧密的circRNA进行综述,期望为喉癌的标志物及基因靶向治疗提供参考。

    Abstract:

    Circular RNAs are a class of endogenous RNAs, are characterized by covalently closed continuous loop without 5’ to 3’ polarity and polyadenylated tail and cannot encode proteins. Because of their special circular structures, they have higher tolerance to exonuclease digestion and are more stable than linear RNAs. CircRNAs have been reported to be involved in a wide range of biological processes and play an important role in the occurrence and development of various tumors, which may become an ideal therapeutic target for tumors. It has been reported that the abnormal expression of circRNA is closely related to the occurrence and development of laryngeal cancer. In this paper,domestic and overseas literatures about several circRNAs closely related to laryngeal carcinoma were reviewed so as to provide reference for gene-targeted therapies and biomarkers of laryngeal carcinoma

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  • 收稿日期:2021-06-07
  • 最后修改日期:2021-08-15
  • 录用日期:2021-08-16
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