B淋巴细胞诱导成熟蛋白-1在变应性鼻炎中的研究进展
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1.山西医科大学;2.山西医科大学附属人民医院耳鼻咽喉头颈外科

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Research progress of B lymphocyte induced mature protein-1 in allergic rhinitis
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    摘要:

    变应性鼻炎(AR)是特异性免疫球蛋白E(Ig E)介导的鼻黏膜非感染性慢性炎症性疾病,以Th2及其分泌的IL-4、IL-5参与主要炎症过程。B淋巴细胞诱导成熟蛋白-1(Blimp-1)是一种含锌指基序的转录抑制因子,调控T细胞发育、分化和功能,对活化T淋巴细胞增殖分化和免疫自稳有重要的调节作用。鉴于Blimp-1对于下呼吸道及其他变应性炎症反应疾病有抗炎作用,深入探寻Blimp-1在AR发生发展中可能的作用,对研究AR的发病机制、新的治疗方法、改善症状、降低并发症的产生具有重大意义。因此,本文围绕Blimp-1与AR的关系进行综述。

    Abstract:

    Allergic Rhinitis (AR) is an inflammatory reaction mediated by specific immunoglobulin E (IgE). IL-4 and IL-5 secreted by Th2 are the main inflammatory factors. B lymphocyte-inducible maturation protein-1 (Blimp-1) is a zinc finger motif-containing transcriptional repressor that regulates T cell development, differentiation and function, and has important regulatory roles in the proliferation and differentiation of activated T lymphocytes and immune self-stabilization. Given the anti-inflammatory effects of Blimp-1 on the lower respiratory tract and other allergic inflammatory response diseases, an in-depth exploration of the possible role of Blimp-1 in the development of AR is of great significance in studying the pathogenesis of AR, new therapeutic approaches, improving symptoms, and reducing the development of complications. Therefore, this paper provides a review around the relationship between Blimp-1 and AR.

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  • 收稿日期:2021-06-11
  • 最后修改日期:2021-08-08
  • 录用日期:2021-08-10
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