NLRP3炎性小体在变应性鼻炎中作用的研究进展
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1.北京大学解放军医院教学医院;2.战略支援部队特色医学中心耳鼻咽喉头颈外科

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战略支援部队特色医学中心指令性课题 课题编号:19ZX74


Advances in research on the role of NLRP3 inflammasome in allergic rhinitis
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1.PLA 306th Hospital/Teaching Hospital of Peking University Health Science Center;2.Otorhinolaryngology Head and Neck Surgery, Special Medical Center of Strategic Support Forces

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    摘要:

    变应性鼻炎是一种以免疫球蛋白E介导多种免疫细胞、细胞因子和炎症介质等参与的鼻黏膜非感染性炎性反应性疾病,鼻腔黏膜炎症反应是变应性鼻炎的重要病理机制之一。NLRP3(NOD-like receptor protein 3, NLRP3)炎性小体活化诱导半胱氨酸蛋白酶1(caspase-1)前体转化,促进炎症细胞因子白介素1β(Interleukin-1β, IL-1β)和白介素18(Interleukin-18, IL-18)表达,参与变应性鼻炎的炎性级联反应过程,对变应性鼻炎的发生发展起促进作用,应用NLRP3炎性小体相关通路抑制剂可抑制下游炎性细胞因子表达,减轻变应性鼻炎症状。本文围绕NLRP3炎性小体在变应性鼻炎中的作用调控机制,和适用于变应性鼻炎治疗的NLRP3炎性小体相关通路抑制剂的相关研究综述如下。

    Abstract:

    Allergic rhinitis is a non-infectious inflammatory disease of nasal mucosa mediated by immunoglobulin E, which involves a variety of immune cells, cytokines and inflammatory mediators. Inflammation of the nasal mucosa is one of the important pathological mechanisms of allergic rhinitis. The activation of NLRP3(NOD-like receptor protein 3, NLRP3) inflammasome induces the maturation and transformation of caspase-1 precursor, promotes the expression of inflammatory cytokines interleukin-1β(IL-1β) and interleukin-18(IL-18), participates in the inflammatory cascade reaction of allergic rhinitis, and promotes the occurrence and development of allergic rhinitis. The application of NLRP3 inflammasome related inhibitors can inhibit the expression of downstream inflammatory cytokines and alleviate the symptoms of allergic rhinitis. This article summarizes the related research on the regulation mechanism of NLRP3 Inflammasomes in allergic rhinitis and NLRP3 inflammasome-related pathway inhibitors suitable for the treatment of allergic rhinitis.

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  • 收稿日期:2021-06-24
  • 最后修改日期:2021-08-04
  • 录用日期:2021-08-05
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