Objective:To investigate the clinical characteristics, treatment methods and therapeutic effect of deep-neck space infection, summarize the clinical treatment experience,improve the level of disease awareness, and guide the clinical treatment. Methods: The clinical data of 41 patients with deep-neck space infection who were admitted to the Department of Otolaryngology, Head and Neck Department of the First Hospital of Shanxi Medical University from July 2017 to November 2020 were retrospectively analyzed. Results: Among the 41 patients, there were 28 males and 13 females, the male to female ratio was 2.2:1, and the average age was 50 years old.Sixteen patients (39.0%) had clear causes, and the most common causes were congenital branchial cleft cyst and odontogenic infection.The most common clinical symptoms are neck pain, sore throat and fever.Thirty-one patients had multiple interstitial infections, the most frequently involved interstitial space being parapharyngeal space.Thirty-three patients received incision and drainage for neck abscess, among which 4 patients received tracheotomy at the same time, 3 patients received puncture and drainage for neck abscess guided by B-ultrasound, and 5 patients received conservative treatment.The pus culture of 24 patients was positive, among which 4 patients were infected with a variety of mixed microorganisms, the most common of which was Streptococcus. Sensitive antibiotics were selected for treatment according to the result of pus culture identification and drug sensitivity during the course of disease.Postoperative complications occurred in 15 patients, which could be alleviated by active treatment.All the 41 patients obtained satisfactory curative effect after the above treatment, and no recurrence of infection during follow-up.? Conclusion:Deep-neck space infection is still a critical and severe disease in Otolaryngology, Head and Neck Surgery. If treated correctly and promptly, the prognosis is good. Otherwise, it can lead to serious complications and threaten life.Cervical abscess incision and drainage is still an important treatment.