3D printing technology has been widely used in the field of biomedicine in recent years, although there are few reports on its application in the field of nose-skull base surgery, but with its advantages such as rapid prototyping and three-dimensional reproduction, it has a broad application prospect in the field of nose-skull base surgery. This article provides an overview of the development status of 3D printing technology in the field of nose-cranial base surgery. It’s clinical application mainly involves Repair of nasal-skull base defect, preoperative planning and preoperative operation simulation, anatomy teaching and training, patient education etc. At the same time, its development prospect is prospected.