Abstract:The basic pathological feature of chronic rhinosinusitis is chronic inflammatory reaction of the nasal sinus Mucosa, the pathogenesis of which has not been fully elucidated, but it is believed that the disturbance of immune response and abnormal differentiation of immune cells are closely related. Studies have shown that various subtypes of t cells and their secretion of inflammatory factors. TH1 cells mediated cellular immunity, Th2 cells mediated humoral immunity, the proportion of Th1 and Th2 cells was unbalanced in CRS patients. When the Th2 immune activity was excessively increased, Th2 cells infiltrated the nasal Mucosa, the levels of IL-4 secreted by Th2 cells in Nasal Mucosa and serum were significantly increased. IL-4 can inhibit TH1 cells, enhance the interaction between t cells and B cells, and further promote the humoral immune response. In this paper, the mechanism of CD4+T cells and CD8+T cells in CRS is reviewed.