Abstract:Allergic rhinitis (AR) is a noninfectious inflammatory disease of the nasal mucosa mediated by IgE and important immunological characterized by the imbalance of Th1/Th2/Th17/Treg cells. The silent information regulator 2 homolog 1(SIRT1), Class III family of histone deacetylase enzymes, plays a significant role in DNA repair and apoptosis, muscle and adipose differentiation, neuron proliferation and differentiation, mitochondrial biogenesis, metabolism, inflammatory response, and oxidative stress. The recent researches on SIRT1 in allergic diseases mainly focus on rheumatoid arthritis, systemic lupus erythematosus and asthma, and there are few studies in AR. This article summarizes the relevant researches on the role of SIRT1 in AR.