Objective The objective is to analyze the general clinical features of unilateral total sudden deafness,and to explore the prognostic factors.Methods The clinical data of 127 cases with unilateral total sudden deafness were retrospectively studied from September 2019 to May 2021 in the Department of Otolaryngology of our hospital,including general conditions, accompanying symptoms, accompanying diseases, hearing characteristics, laboratory examination, treatment effect, etc.Chi-square test and multivariate binary Logistic regression were used to analyze the effects of gender, age, affected ear side, the time before treatment, accompanying diseases (hypertension, diabetes, heart disease), accompanying symptoms (tinnitus,vertigo/dizziness), and laboratory tests (folic acid, vitamin B12, homocysteine) on prognosis.Results Among 127 cases of unilateral total sudden deafness,113 cases (88.98%) were accompanied by tinnitus,91 cases (71.65%) by vertigo, the total effective rate was 41.73%. Single-factor analysis revealed a statistically prognostic association between age (P=0.016<0.05), the time before treatment (P=0.003<0.05), and associated with dizziness / dizziness (P=0.017<0.05).However,there was no statistical significance in the influence of gender,affected ear,associated basic diseases (hypertension,diabetes,heart disease), tinnitus and laboratory tests (folic acid, vitamin B12, high homocysteine) on prognosis.Multivariate analysis showed that the time before treatment(P=0.006<0.05) and whether with the vertigo/dizziness (P=0.037<0.05) were independent risk factors for prognosis.The effective rate of the group with the time before treatment ≥3 days vs the group with the time before treatment＜3 days(OR=0.311,95%CI=0.134-0.720,P=0.006).The effective rate of the group with vertigo/dizziness vs the group without vertigo/dizziness(OR=0.385,95%CI=0.157-0.944,P=0.037).Conclusion Unilateral total sudden deafness is often accompanied by tinnitus and vertigo/dizziness. And the age ≥40 years,the time before treatment ≥3 days and accompanied by vertigo/dizziness suggest poor prognosis.And,the time before treatment ≥3 days and accompanied by vertigo/dizziness are independent risk factors,which can provide theoretical basis for clinical prognosis evaluation and treatment of unilateral total sudden deafness.