Abstract: Objective To retrospectively analyze the medical records of 10 patients with laryngeal ulcer disease as the main presentation, and to provide reference for clinicians in the diagnosis and treatment of such diseases. Methods The clinical manifestations, lesion sites, ulcer characteristics, diagnosis and treatment process and pathological diagnosis of the included cases were analyzed, and the clinical characteristics of the disease were expounded based on the typical cases and literature review. Results 6 cases of laryngophthisis (One case was located in supraglottic portion, 4 cases was located in glottic region, 1 case was located in infraglottic?portion), 2 cases of ulcerative pharyngitis, 1 case of lymphoma, 1 case of hypopharyngeal cancer were diagnosed. Conclusion It is necessary to make definite diagnosis for different ulcer diseases of larynx and throat. Besides simple ulcer lesions, specific infection, malignant tumor and other diseases should be considered. Only after definite diagnosis can exact curative effect be obtained.