Abstract:Objective:This study aimed to investigate the role of lncRNA-mediated ceRNA network in AR pathophysiology and its potential regulatory functions in programmed cell death. Methods: Allergic rhinitis patients and normal subjects were included, whole blood was taken for RNA sequencing analysis, and differentially expressed lncRNA, miRNA and mRNA were screened to construct a lncRNA-miRNA-mRNA regulatory network based on ceRNA theory. GO and KEGG enrichment analyses were employed to predict the potential biological functions of mRNAs in the ceRNA network. Subsequently, the differentially expressed mRNAs interacted with programmed cell death-related genes, and a new ceRNA network was constructed, and target organ localization network analysis was performed on mRNAs in the network. Results: Based on bioinformatics analysis, a total of 5 lncRNAs, 4 miRNAs and 46 mRNAs were extracted, and the ceRNA network of lncRNA-mediated up-regulation and down-regulation in AR was constructed. Functional enrichment analysis showed that it was significantly enriched in "calcium signaling pathway", "PI3K/AKT signaling pathway" and "ERK1 and ERK2 cascade". Next, we constructed a programmed cell death-related ceRNA regulatory network for two lncRNAs, AC008394.1 and HCP5. In the target organ localization analysis of mRNAs in the ceRNA network, it was found that they were mostly expressed in neuroimmune-related organs. Conclusion: This study constructs a new ceRNA network in AR, and preliminarily explores that HCP5-mediated ceRNA network may play a role in AR by affecting apoptosis. It provides new insights and potential research options for the study of AR pathogenesis.