ObjectiveTo investigate the efficacy of partial resection of tongue base and uvulopalatopharyngoplasty in the treatment of type Ⅲ obstructive sleep apnea hypopnea syndrome (OSAHS).MethodsTwenty patients of type Ⅲ OSAHS were enrolled from Dec 2019 to May 2021, aged 25-70 years with an average age of 43 years. After admission, relevant examinations were performed to exclude contraindications of surgery and general anesthesia. Partial resection of tongue and tongue base combined with uvulopalatopharyngoplasty was performed for all patients. Polysomnography was repeated in 6 to 24 months after surgery.ResultsOf all the 20 patients, 13 were effective (65%) and 7 (35%) were ineffective after surgery. But there were statistically significant differences in preoperative and postoperative Epworth sleep scale and clinical symptom scores of these 7 patients (P < 0.05).ConclusionTongue base midline resection combined with uvulopalatopharyngoplasty is a relatively safe and effective surgical method for type Ⅲ OSAHS patients.