Objective To investigate the clinical characteristics of patients with sudden sensorineural hearing loss (SSNHL) complicated with metabolic syndrome and the influence of various related factors on the prognosis.Methods Clinical data of 98 SSNHL patients complicated with metabolic syndrome hospitalized in our department from April 2019 to Aug 2021 were retrospectively analyzed. Of them, unilateral ear was affected in 56 cases in left ear and 48 cases in right ear, with a total of 104 ears. The influencing factors of therapeutic effect in SSNHL patients complicated with metabolic syndrome were analyzed.Results Of all the 104 ears (98 cases), 62 were ineffective, 29 were effective, 4 were markedly effective, and 9 were cured, with a total effective rate of 40.38%. The case proportions of onset time ≥7 days, concomitant dizziness, and no administration of batroxobin in the ineffective group were higher than those in the effective group (P＜0.05), and the prognosis of low frequency hearing loss type was better than those of other types (P＜0.05). The differences in patients’ age and gender, ear side, hearing loss type (high frequency type, flat type, profound type), prothrombin time, active partial thromboplastin time, fibrinogen, thrombin time, and platelet count between the two groups were all statistically insignificant (P>0.05). Logistic regression analysis showed that onset time ≥7 days and concomitant dizziness were independent risk factors affecting the therapeutic outcome of SSNHL patients complicated with metabolic syndrome (P<0.05 and OR>1).Conclusion With low therapeutic effective rate, onset time ≥7 days and concomitant dizziness are independent risk factors affecting the treatment outcome of SSNHL patients complicated with metabolic syndrome, which attention should be paid to in clinical treatment.