太原市1382例变应性鼻炎患者变应原谱分析
DOI:
作者:
作者单位:

1.山西医科大学第一临床医学院;2.浙江大学过敏研究中心

作者简介:

通讯作者:

基金项目:

国家重点研发计划项目(项目名称:蒿花粉和螨虫重要过敏原组分鉴定以及检测试剂开发(No:2019YFE0106600)


Allergenic spectrum analysis of 1382 patients with allergic rhinitis in Taiyuan
Author:
Affiliation:

山西医科大学第一临床医学院

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
    摘要:

    摘要:目的 研究太原地区变应性鼻炎(AR)患者变应原的分布特征,为该地区AR的合理防治提供参考依据。方法 回顾性分析我院2020年1月—2021年12月间就诊的1382例疑似AR且行血清特异性IgE检测患者的临床资料,使用SPSS 26.0软件对数据进行分析与总结。 结果 943例(68.23%)患者血清特异性IgE(sIgE )呈阳性反应,其中艾蒿(48.26%)、豚草(21.56%)、室内尘螨组合(19.10%)为主要变应原;吸入性变应原阳性率(34.88%)显著高于食入性变应原(3.40%)(P<0.05);不同年龄间变应原阳性率差异有统计学意义,随着患者年龄增加,变应原呈降低趋势(P<0.05);不同病程间变应原阳性率差异有统计学意义(P<0.05),其中2-3年最高(80.00%);不同月份间变应原阳性率差异有统计学意义(P<0.05),其中8月最高(79.89%);不同季节间艾蒿、豚草变应原阳性率差异有统计学意义(P值均<0.05),以夏秋季高发;患者变应原阳性个数组合从1种到12种均有分布,其中2种组合最高(15.63%)。 结论 太原地区的主要变应原是艾蒿、豚草、室内尘螨组合。绝大数患者为多重致敏,年龄、病程、季节也是影响变应原阳性率的因素之一。

    Abstract:

    Abstract: Objective To study the distribution characteristics of allergens in patients with allergic rhinitis (AR) in Taiyuan, and to provide reference basis for the rational prevention and treatment of AR in this area. Methods The clinical data of 1382 patients with suspected AR and serum specific IgE from January 2020 to December 2021 were analyzed retrospectively 26.0 software to analyze and summarize the data. Results Serum specific IgE (SiGe) was positive in 943 patients (68.23%), among which Artemisia argyi (48.26%), ragweed (21.56%) and indoor dust mite combination (19.10%) were the main allergens; The positive rate of inhaled allergens (34.88%) was significantly higher than that of ingested allergens (3.40%) (P < 0.05); There was significant difference in the positive rate of allergens among different ages. With the increase of patients' age, the positive rate of allergens decreased (P < 0.05); There was significant difference in the positive rate of allergens among different disease courses (P< 0.05), and the highest rate was in 2-3 years (80.00%); There was significant difference in allergen positive rate among different months (P < 0.05), and the highest rate was in August (79.89%); There was significant difference in allergen positive rate between Artemisia annua and ragweed in different seasons (P < 0.05), which was high in summer and autumn; The number of allergen positive combinations ranged from 1 to 12, and the two combinations were the highest (15.63%). Conclusion The main allergens in Taiyuan are the combination of Artemisia annua, ragweed and indoor dust mite. The majority of patients have multiple sensitization, and age, course of disease and season are also one of the factors affecting the positive rate of allergens.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
历史
  • 收稿日期:2022-05-17
  • 最后修改日期:2022-06-29
  • 录用日期:2022-07-05
  • 在线发布日期:
新投稿系统运行通知

作者投稿请直接点击左侧“作者登录”,请不要进入旧版入口。如登录或投稿中遇到任何问题,请联系电话13311390237。谢谢!

关闭