内质网应激研究进展及其与气道变应性炎症的关系
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1.内蒙古自治区人民医院;2.内蒙古自治区人民医院临床医学研究中心;3.内蒙古自治区人民医院科研处

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内蒙古自治区科技计划项目(2020GG0082);内蒙古自治区科技重大专项课题(2017年);内蒙古自治区自然科学基金项目(2021LHMS08067)


Advances in studies on endoplasmic reticulum stress and its relationship with airway allergic inflammation
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    摘要:

    内质网(endoplasmic reticulum,ER)是真核生物维持细胞正常功能及内环境稳定的重要细胞器。ER稳态被打乱,如蛋白质加工负荷过大、营养供应不足、病毒感染和氧化还原反应失衡等就会出现内质网应激(endoplasmic reticulum stress,ERS),引发Ca2+失衡、内质网超载、细胞凋亡途径激活等异常反应,从而影响体内某些重要蛋白质的表达、诱导炎症反应及参与细胞凋亡,导致许多慢性炎症性和自身免疫性疾病的发生。已有研究证实,ERS参与了肥胖症、神经退行性疾病、糖尿病、肺纤维化等多种疾病的发病机制。关于ERS在气道变态反应性炎性疾病(allergic airway inflammation Disease,AAID)中的作用方面,目前国内外也有一些最新的研究成果。本文将从ERS介导的免疫调节机制方面进行综述,进一步探讨ERS在AAID发病中可能的作用,以期为未来相关疾病的研究和治疗策略提供新思路。

    Abstract:

    Endoplasmic reticulum (ER) is an important organelle for eukaryotes to maintain normal cell function and stable internal environment. When ER homeostasis is disrupted, such as excessive protein processing load, insufficient nutrition supply, virus infection, calcium imbalance and redox imbalance, endoplasmic reticulum stress (ERS) will occur, which will lead to adverse reactions such as Ca2+ imbalance, endoplasmic reticulum overload, apoptosis pathway activation and so on. ERS can affect the expression of some important proteins, induce inflammation and participate in apoptosis, thus participate in the occurrence of many chronic inflammatory and autoimmune diseases. Studies have confirmed that ERS is involved in the pathogenesis of obesity, neurodegenerative diseases, diabetes, pulmonary fibrosis, bronchial asthma and other diseases. Regarding the role of ERS in airway allergic inflammatory disease (AAID), there are some latest research results at home and abroad. This article will review the immune regulation mechanism mediated by ERS, and further explore the possible role of ERS in the pathogenesis of AAID, in order to provide new ideas for future research and treatment strategies of related diseases.

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  • 收稿日期:2022-05-31
  • 最后修改日期:2022-08-08
  • 录用日期:2022-08-08
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