The Affiliated Hospital of Qingdao University
探讨鼻腔鼻窦低级别非肠型腺癌的临床特点及治疗方式。方法 收集分析2013年-2022年于青岛大学附属医院确诊的4例鼻腔鼻窦低级别非肠型腺癌患者的临床、影像学、病理学及随访预后资料。 结果 4例患者中，男1例，女3例，发病年龄段为：33～70岁。2例查体发现右侧鼻腔肿物，1例右侧鼻塞、流涕1年余，1例左侧面部疼痛4月余。3例患者行手术治疗，1例术后接受放疗。免疫组化结果：CK7阳性表达，CK20、CDX2 和 villin 均阴性。3例手术患者随访至今，均无复发及转移。1例未行治疗，因并发中耳癌去世。结论 鼻腔鼻窦低级别非肠型腺癌临床罕见，发病隐匿，确诊需根据病理诊断，手术治疗有效。
Objectives To analyze the clinical features and treatment of low-grade non-intestinal-type sinonasal adenocarcinoma (LG non-ITAC)of the nasal cavity and paranasal sinuses. Methods Clinical, imaging,pathological and prognosis data of 4 patients, who were hospitalized in the Affiliated Hospital of Qingdao University, from 2013 to 2022 with histopathologically proved LG non-ITAC in the nasal cavity and paranasal sinuses were reviewed. Results Among the 4 patients, 1 male and 3 female, the age of onset was 33~70 years old.Two cases found a right nasal mass, one case had right nasal congestion and runny nose for more than 1 year, and one case had left facial pain for more than 4 months.Three patients underwent surgery treatment and one received postoperative radiotherapy.Immunohistochemistry: CK7 positive expression, CK20, CDX2 and villin were negative.Three surgical patients had no recurrence or metastasis.One case died without treatment and died of complicated middle ear malignancy. Conclusions LG non-ITAC of the nasal cavity and paranasal sinuses in clinical is rare, with insidious onset, definite histopathological diagnosis is needed, and surgical treatment is effective.