Abstract:Objective The objective of this study is to evaluate the clinical characteristics of tinnitus patients, and to provide profiles for the diagnosis and treatment of tinnitus. Methods This study included 854 tinnitus patients seeking treatment between January 2018 and December 2021 from Jiangsu Provincial People's Hospital (The First Affiliated Hospital of Nanjing Medical University). We collected clinical characteristics, and provided sex, age, tinnitus laterality, tinnitus time, tinnitus persistence, hearing loss, tinnitus loudness, tinnitus main tone matching, self-rating anxiety scale and Pittsburgh sleep quality index as independent variables, and the tinnitus handicap inventory was used as dependent variable to performed multivariate correlation analysis. Results 854 tinnitus patients with a total of 1290 tinnitus ears. The average age of the tinnitus patients was 46.7 ± 14.65 years old, and the largest proportion was in the age group of 30 to 60 years old (65.2%, 557/854). Most patients with tinnitus were persistent. Bilateral tinnitus and unilateral tinnitus each accounting for half, and symmetric tinnitus was more common in patients with bilateral tinnitus (97%,423/ 436). 55% (467/854) and 58.8% (502/854) of the tinnitus patients had different degrees of anxiety and sleep disorders, respectively. 33% (426/1290) of tinnitus ears accompanied varying degrees of hearing loss. Tinnitus Handicap Inventory was mainly graded from 2 to 3 (18~56 score, 83.3%, 711/854); The tone matching was more common in high frequencies (4~8 kHz, 77.3%, 997/1290); Tinnitus loudness was more common with low to medium loudness (< 60dB, 82.3%, 1062/1290). Tinnitus persistence ( β= -0.690, P=0.011), hearing loss (Spearman =0.140, P<0.001), tinnitus loudness (β=0.135, P=0.002; Spearman =0.140, P<0.001), Pittsburgh Sleep quality index score (β=0.049, P=0.001; Spearman =0.214, P<0.001), self-rating anxiety scale (β=0.055, P<0.001; Spearman =0.241, P<0.001) were related to tinnitus handicap inventory score. Conclusion Currently, the tinnitus patients are gradually younger, and most of them are accompanied by symptoms such as anxiety, sleep disturbance, and hearing loss. Most of tinnitus patients seeking treatment in our hospital had low to moderate tinnitus severity, the tinnitus tones were mostly high frequency, and most of them were low to medium loudness tinnitus. The severity of tinnitus was associated with tinnitus persistence, hearing loss, tinnitus loudness, sleep disturbance and anxiety. Therefore, we should focus on developing personalized tinnitus treatment plans for these tinnitus patients in the future.