鼻腔鼻窦Rosai-Dorfman病的临床病理特征分析
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中国人民解放军总医院

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The clinical and pathological features analysis of rhinosinusal Rosai-Dorfman diseaseZhou Xuejun1, Chen Lei1, Yuan Hu1, Wang Rongguang1, Liu Qiong1, Chen Wei2, Yuan Jing2*
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Chinese PLA General Hospital

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    摘要:

    探讨发生在鼻腔鼻窦的Rosai-Dorfman病的临床、病理特征。方法:报道3例鼻腔鼻窦Rosai-Dorfman病、总结临床病理特征并进行相关文献复习。结果:发生在鼻腔鼻窦的Rosai-Dorfman病临床以鼻塞为主。病理组织学特点为在淋巴、浆细胞背景下,见弥漫浸润的窦组织细胞,局部见“封入”现象。免疫组织化学染色示肿瘤细胞表达CD68,S-100。结论:Rosai-Dorfman 病是一种组织细胞增生性病变,临床表现不特异。病理学诊断为金标准,治疗效果不佳。

    Abstract:

    To analysis the clinical and pathological features of Rosai-Dorfman disease (RDD) in nasal cavity and paranasal sinus. Methods Retrospectively observed clinical and pathological data of 3 cases with rhinosinusal RDD, and reviewed the literature.Results Rosai-Dorfman disease occurring in the nasal cavity and sinus was mainly characterized by nasal obstruction. The histopathological features were diffuse infiltrating sinus histocytosis, in the background of lymphocytes and plasma cells, "sealing" phenomenon were seen occasionally. Immunohistochemical staining showed S-100, CD68 expression in tumor cells. Conclusion Rosai-Dorfman disease was a histocytoproliferative disease with nonspecific clinical manifestations. The pathological diagnosis was the gold standard and the treatment response was poor.

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  • 收稿日期:2022-07-25
  • 最后修改日期:2023-05-04
  • 录用日期:2023-05-05
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