环境内分泌干扰物致变应性鼻炎发病的研究进展
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1.兰州大学第一临床医学院;2.兰州大学第一医院

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The effect of Endocrine disrupting chemicals on allergic rhinitis
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1.The first Clinical Medical College,Lanzhou University;2.The first hospital of Lanzhou University

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    摘要:

    变应性鼻炎(Allergic rhinitis,AR )的发病率逐年上升,其发病与环境因素密不可分,其中,环境内分泌干扰物(Endocrine disrupting chemicals,EDCs)是一类可干扰内源性激素的典型环境污染物,流行病学研究显示AR发病与EDCs暴露有一定的关联性。EDCs在 AR发病机制中的作用已有探索性研究,EDCs可通过作用于激素信号通路,促进氧化应激和气道炎症,打破Th1/Th2平衡,引起微生物群失调,调控表观遗传调控等途径引起呼吸道变应性炎性反应,说明EDCs暴露可能是诱发AR的一个重要因素。本文就EDCs来源、分类、污染现状、特性其对AR发病的影响和可能的作用机制进行综述。

    Abstract:

    The incidence of Allergic rhinitis (AR) is increasing year by year, and its pathogenesis is closely related to environmental factors. Among them, environmental Endocrine disrupting chemicals (EDCs) are typical environmental pollutants that interfere with endogenous hormones. Epidemiological studies have shown that there is a certain correlation between the incidence of AR and EDCs exposure. There have been exploratory studies on the role of EDCs in the pathogenesis of AR. EDCs can promote oxidative stress and airway inflammation by acting on hormone signaling pathways, break Th1/Th2 balance, cause microbiota dysregulation, regulate epigenetic regulation and other pathways to cause respiratory allergic inflammatory response. These results suggest that EDCs exposure may be an important factor in inducing AR. In this paper, the source, classification, pollution status, characteristics and possible mechanism of EDCs about AR will be reviewed.

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  • 收稿日期:2022-10-12
  • 最后修改日期:2022-11-25
  • 录用日期:2022-11-28
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