Objective:?To explore the role of the 20 m6A methylation regulators in the occurrence, development, and prognosis of papillary thyroid cancer (PTC). Methods:?A total of 395 cases of papillary thyroid carcinoma (PTC) data were obtained from the TCGA dataset. The differentiated expressed of the 20 m6A regulators were compared, and the correlation between the clinical data of PTC (gender, T stage, cervical lymph node metastasis, etc.) was analyzed. The prognostic-related m6A regulators were identified, as well as the survival rate and the risk signature were established using the LASSO regression. In addition, the relationship between the prognostic-related m6A regulators and the immune cells was further explored. All the statistical analysis work was performed by the R foundation. A P<0.05 was considered statistically significant. Results:?A total of 15 m6A-regulated genes were up-regulated in PTC, and three m6A genes were down-regulated. HNRNPC and IGF2BP2 were positively and significantly correlated and ALKBH5 was negatively correlated to the lymph node metastasis of PTC. HNRNPC and IGF2BP2 were correlated to the T stage. YTHDF1 was correlated to sex. METTL14, YTHDC1, YTHDF2, and HNRNPA2B1 were correlated to the clinical stage of PTC. PTC patients with the higher expression of FTO, IGF2BP1 and YTHDF3 resulted in worse survival. YTHDF3 was correlated to the endothelial cell, the macrophage cell, NK cell and T cell CD4+; FTO was correlated to the macrophage cell, NK cell, T cell CD4+ and T cell CD8+. Conclusion:?The?m6A regulators play important role in the occurrence and development of PTC, as well as severed as potential biomarkers for PTC treatment.