过敏性鼻炎(AR)患者外周血I型2型T细胞与炎症指标的变化及相关性分析
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海安市人民医院耳鼻喉科

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国家自然科学基金委员会自助项目(编号:81970865)


Changes and correlation analysis of peripheral blood type I type 2 T cells and inflammatory markers in patients with allergic rhinitis (AR)
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海安市人民医院

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    摘要:

    目的:分析过敏性鼻炎(AR)患者外周血I型/2型T细胞与炎症指标的变化及相关性。方法:选定本院2020年1月至2022年1月接诊的50例AR患者作为观察组,以及同期门诊体检的50例健康体检者作为对照组,检测、比较两组血清Th1细胞因子[干扰素γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)]、Th2细胞因子[白细胞介素-5(IL-5)、白细胞介素-4(IL-4)]、血清降钙素原(PCT)、C反应蛋白(CRP),对比AR患者中轻度、中重度组血清Th1、Th2细胞因子、血清PCT、CRP,Spearman相关性分析Th1、Th2细胞因子与PCT、CRP的相关性。结果:观察组血清IFN-γ均低于对照组,观察组血清TNF-α、IL-4、IL-5均高于对照组,P<0.05(差异均具有统计学意义)。观察组血清PCT、CRP均高于对照组,P<0.05(差异均具有统计学意义)。中重度组血清IFN-γ均低于轻度组、对照组,中重度组血清TNF-α、IL-4、IL-5均高于轻度组、对照组,P<0.05(差异均具有统计学意义)。中重度组血清PCT、CRP均高于轻度组、对照组,P<0.05(差异均具有统计学意义)。IFN-γ与PCT、CRP呈负相关性(r值=-0.325、-0.428),TNF-α、IL-4、IL-5与PCT、CRP均呈正相关性,P<0.05(r值=0.502、0.493、0.496、0.413、0.467、0.034)(差异均具有统计学意义)。结论:AR患者血清Th1、Th2细胞因子呈异常表达,且血清Th1、Th2细胞因子与炎症因子PCT、CRP存在一定相关性,临床可通过检测血清Th1、Th2细胞因子含量,评估AR患者疾病严重程度、炎症反应等。

    Abstract:

    Objective: To analyze the changes and correlations of peripheral blood type I/type 2 T cells and inflammatory indexes in patients with allergic rhinitis (AR). Methods: 50 AR patients admitted to our hospital from January 2020 to January 2022 were selected as the observation group, and 50 healthy people who underwent physical examination in the outpatient clinic during the same period were selected as the control group. Serum Th1 cytokines were detected and compared between the two groups[ Interferon gamma (IFN-γ), tumor necrosis factor-α (TNF-α)], Th2 cytokines [interleukin-5 (IL-5), interleukin-4 (IL-4)], serum Procalcinin (PCT), C-reactive protein (CRP), compared with moderate-to-severe AR patients, serum Th1, Th2 cytokines, serum PCT, CRP, Spearman correlation analysis Th1, Th2 cytokines and PCT, CRP Correlation. Results: The serum IFN-γ in the observation group was lower than that in the control group, and the serum TNF-α, IL-4 and IL-5 in the observation group were higher than those in the control group, P<0.05 (both differences were statistically significant). Serum PCT and CRP in the observation group were higher than those in the control group, P<0.05 (both differences were statistically significant). The serum IFN-γ in the moderate-severe group was lower than that in the mild group and the control group, and the serum TNF-α, IL-4 and IL-5 in the moderate-severe group were higher than those in the mild group and the control group, P<0.05 (all differences were statistically significant). learning meaning). The serum PCT and CRP in the moderate-severe group were higher than those in the mild group and the control group, P<0.05 (both differences were statistically significant). IFN-γ was negatively correlated with PCT and CRP (r value=-0.325, -0.428), and TNF-α, IL-4, IL-5 were positively correlated with PCT and CRP, P<0.05 (r value=0.502) , 0.493, 0.496, 0.413, 0.467, 0.034) (differences are all statistically significant). Conclusion: Serum Th1 and Th2 cytokines are abnormally expressed in AR patients, and there is a certain correlation between serum Th1 and Th2 cytokines and inflammatory factors PCT and CRP. Clinically, the serum Th1 and Th2 cytokine levels can be detected to evaluate the severity of AR patients. , inflammatory response, etc.

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  • 收稿日期:2022-10-24
  • 最后修改日期:2023-03-16
  • 录用日期:2023-03-17
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