Abstract:Objective The aim of this study was to analyze the long term clinical outcomes of vertical partial laryngectomy (VPL) in management of patients with glottic carcinoma, and to explore potential prognostic factor on survival outcomes. Methods In this series, records of 548 consecutive glottic carcinoma patients from Jan. 2005 to Dec. 2010 were retrospectively reviewed. The long term clinical outcomes including overall survival (OS) and disease-frees survival (DFS) of patients who underwent primary VPL were evaluated. Cox regression models were used to assess the prognostic agents that may predict survival outcomes. Results In all, 537 (98.0%) patients were male and 11 (2.0%) were female, with a mean age of 59.0±9.4 years (range: 34 - 89 years). One hundred and sixty-nine patients (30.8%) were at T1 stage, 316 patients (57.7%) were at T2 stage, 63 patients (11.5%) were at T3 stage when confirmed to be glottic carcinoma. The 3-, 5- and 10-year OS rates were 96.5%,92.1% and 83.3%, respectively, and the 3-, 5- and 10-year DFS rates were 93.2%,88.0% and 79.6%, respectively. Patients with advanced T stage and greater tumor area experienced inferior survival outcomes (p<0.001). Regarding patients with the same T stage of T2 or T3, those with greater tumor area had poorer survival outcomes (p<0.05). Cox regression models detected that higher T stages, greater tumor area and older age were predictive factors for patients with glottic carcinoma. Conclusion This retrospective study indicates that VPL treatment with excellent survival outcome is a reliable procedure and may be considered as standard therapy for T1-T2 and selected T3 glottic carcinoma patients with poor larynx exposure. Advanced T stage, greater tumor area and age older than 70 years are risk factors of survivals in patients with glottic carcinoma.