Objective To report 15 cases of endoscopic resection of ethmoid sinus osteoma, discuss the surgical method and treatment effect of endoscopic resection of ethmoid sinus osteoma, and summarize the surgical experience of sinus osteoma. Methods The clinical data of 15 patients who underwent endoscopic resection of ethmoid sinus osteoma from June 2018 to April 2022 in the Department of Otolaryngology Head and Neck Surgery of Wuhan First Hospital were retrospectively analyzed. All patients underwent paranasal sinus CT examination, nasal endoscopy, nasal resistance examination and ophthalmology related examinations before surgery. All operations were completed under endoscopic after general anesthesia. The specific operation method was determined after the location and scope of ethmoid sinus osteoma were determined according to CT. The ethmoid sinus osteoma was completely removed. After the operation, the nasal sinus CT and nasal endoscopy were reviewed, and the outpatient department returned regularly. Results 15 patients were pathologically confirmed as ethmoid sinus osteoma after operation. CT of the sinus showed that ethmoid sinus osteoma was completely removed. After 5-48 months of follow-up, the symptoms of the patients, such as nasal congestion, facial pain, headache, purulent discharge, and hypoesthesia, were alleviated or disappeared compared with those before operation. No significant intraorbital and intracranial complications occurred, and no recurrence of osteoma occurred. Conclusion Nasal sinus CT can determine the location and scope of osteoma before operation, which provides a good guarantee for endoscopic sinus surgery. Endoscopic resection of ethmoid sinus osteoma is effective, safe, minimally invasive, and has a good prognosis, which is worthy of clinical application.